Jobs/Positions

1. Postdoctoral position for Molecular Parasitologist/Systems Biologist in Mueller Lab, Population Health & Immunity Division

Upon entry into human liver cells, P. vivax sporozoites take two distinct developmental pathways with some directly developing in tissue schizonts that cause blood infections within 10-12 days, while others become ‘dormant’ hypnozoites, that remain developmentally arrested before reactivating weeks or months later to cause relapsing blood-stage infections. To-date little is know about both the processes that govern this developmental switch are unknown, nor about the molecular epidemiology of relapsing P. vivax infecitons in different epidemiological settings. In our laboratory we investigate P. vivax relapses from two directions:

  • On an epidemiological side, we are investigating the within-host dynamics of P. vivax infections using a combination of in-depth genotyping of well-characterised samples from intensive longitudinal cohorts and mathematical, within host modelling. We are now developing short- and long-amplicon sequencing-based genotyping methods and identity-by-decent analytical methods to determine the genetic relatedness of concurrent and consecutive P. vivax infections.
  • On a mechanistic side, we have started to analyses sporozoite transcriptional, translational and epigenetic patterns to identify potential makers for the developmental fate of sporozoites. We now want to extend these studies in two direction: i) single cell transcriptomic analyses of P. vivax sporozoites and ii) screening sporozoites mRNAs for proteins that interfere with apoptosis in human hepatocytes.

The Post-doctoral Fellow will be responsible for establishing the required laboratory and bioinformatics protocols for both the transcriptomic analyses of field samples and the amplicon sequencing. In particular, s/he will be responsible for short- and long-amplicon sequencing protocol  (using Illumina and PacBio) and establishing single cell protocols (based on FACS sorting and/or DropSeq technologies) for transcriptomic analyses of individual sporozoites that were preserved at endemic sites in the Asia-Pacific. This project will be done in collaboration with the Jex, Barry and Bahlo Labs and the Sequencing Platform at WEHI and our team at the Pasteur Institut in Paris. The position will require close collaboration with endemic country scientist including the mentoring of PhD and MSc students and a willingness to spend time working in the endemic countries.

Candidates should have a PhD in molecular parasitology or systems biology, with a solid knowledge of genomic, transcriptomic and/or analyses (DNA/RNAseq/ChIPseq and bioinformatics analyses).

The position will require a high degree of self-motivation and ability to work independently as well as a willingness to work in international collaborative environment (incl. spending time in malaria endemic countries and/or overseas laboratory). Previous experience in malaria or other tropical infectious diseases, single cell methodologies or high throughput screening would be beneficial but not a requirement.

This position is available for 2 years (with potential extension) starting in 1st or 2nd quarter of 2017. Salary is dependent on qualifications and experience. Up to 17% superannuation and attractive salary packaging options are available.

A position description is available at http://www.wehi.edu.au/senior-research-officer-postdoctoral-scientist

General enquiries can be directed to Professor Ivo Mueller- mueller@wehi.edu.au

Applications should include a Cover Letter, CV and the names of 3 professional referees emailed in pdf format to jobapplications@wehi.edu.au quoting reference WEHI/CAIM in the subject line.

Application closing date:  February 1st 2017

At the Walter and Eliza Hall Institute, we strive to ensure our staff and students enjoy a great working environment. We value diversity and gender equity in our workforce and promote flexible working arrangements for staff to balance working requirements and personal needs.

2. Postdoctoral position for a Molecular Parasitologist/Systems Biologist in Malaria: Parasites & Hosts Unit, Department of Parasites and Insect Vectors Institut Pasteur, Paris

Upon entry into human liver cells, P. vivax sporozoites take two distinct developmental pathways with some directly developing in tissue schizonts that cause blood infections within 10-12 days, while others become ‘dormant’ hypnozoites, that remain developmentally arrested before reactivating weeks or months later to cause relapsing blood-stage infections. While the processes that govern this development switch are unknown, it is likely that the switch is epigenetically pre-determined in sporozoites. We have started to analyses sporozoite transcriptional, translational and epigenetic pattern to identify potential makers for developmental fate of sporozoite. We now want to extend these studies in two directions: i) analyse sporozoites from geographical areas with different relapse patterns and ii) conducting single-cell transcriptomic analyses of isolates with different relapse frequencies.

The Post-doctoral Fellow will be establishing the single-cell protocols (based on FACS sorting and/or single cell technologies) for transcriptomic analyses of individual sporozoites. Initially these protocols will be developed using sporozoites from culturable parasites available at Institute Pasteur (i.e. P. falciparum and/or P. berghei). Once established, an in-depth single cell analysis of sporozoites of the relapsing monkey parasite P. cynomolgi will be undertaken. Lastly, working with researchers based in Pasteur Institute International Network Institute based in P. vivax endemic countries (e.g. Cambodia, Madagascar and/or French Guyana), we will establish systems for producing sporozoites using standard membrane feeding assay and conduct single-cell analyses of sporozoites from areas with differing P. vivax relapse phenotypes. In addition, the postdoc will be responsible for supervising the work done by our technicians in our high-throughput molecular and sero-epidemiology laboratory.

The position will require a high degree of self-motivation and ability to work independently as well as a willingness to collaborate closely with colleagues at the Walter + Eliza Hall Institute in Melbourne, Australia and with endemic country scientist (including spend time working in the endemic countries and mentor of PhD and MSc students).

Candidates should possess a PhD in molecular parasitology or systems biology with a solid knowledge of genome and/or transcriptome analyses (DNA/RNAseq and bioinformatics analyses). Experience in single cell and high-throughput approaches would be beneficial but not a requirement.

This position is available for 2 years (with potential extension) starting in the 1st or 2nd quarter of 2017.

Enquires may be directed to: Prof. Ivo Mueller, Head Malaria: Parasites and Hosts Unit, Department of Parasites and Insect Vector, Institut Pasteur, Rue de Docteur Roux 28, Paris, France  (ivo.mueller@pasteur.fr).

3. Postdoctoral position, Emory University, US

Emory University’s “International Center for Malaria Research Education and Development (ICMRED)”, located within the School of Medicine, the Emory Vaccine Center and Yerkes Research Center, is seeking multiple postdoctoral research associates to join large systems biology consortia supported by the National Institutes of Health (NIH/NIAID) and the Defense Advanced Research Project's Agency (DARPA) to accomplish goals of the “Malaria Host-Pathogen Interaction Center" (MaHPIC, see http://systemsbiology.emory.edu) and the “Host Acute Models of Malaria to study Experimental Resilience" (HAMMER) projects, respectively.

The MaHPIC and HAMMER consortia study and model malaria infections longitudinally in non-human primates (NHPs) including blood, bone marrow and other tissue analyses (and cells therefrom), with the application of cutting-edge technologies and disciplines including telemetry, physiology, immunomics, high-content flow cytometry, epigenomics, transcriptomics, proteomics, metabolomics, lipidomics, histopathology, bioinformatics and mathematical modeling to deliver a dynamic, multi-angle integrated view of host-parasite interactions, immune responses, physiology and pathogenesis. Goals also include revealing new targets for intervention, including host-directed targets and strategies for developing therapies to improve human host resilience to infection.  The research is both hypothesis driven and generating, and clinical, parasitological, immunological, molecular, cell biological, and biochemical skills and assays are also critical to validate research findings

Some areas of focus include:

  • Analysis of multiple big data sets and time series, from longitudinal infections (by multiple Plasmodium species (emphasis on P. vivax, P. cynomolgi, P. knowlesi, and P. coatneyi), and involving multiple primate host; NHPs and humans), and performing analyses and integration to seek omics correlates of clinical outcome and symptoms (e.g., degree of illness and disease severity) and mechanistic connections between different data types.
  • Analysis of the various high-throughput data with the goal of investigating the host biological networks activated by malaria parasites and simultaneously assessing changes in the parasite’s gene expression and biology. 
  • Designing, implementing, and analyzing experiments focusing on host immunology and physiology in response to infection by malaria parasites. A major overarching goal of this work is to understand the host-pathogen infection processes and responses, and identify aspects that enable the host to be more or less resilient to disease outcomes due to the malaria parasite.

Candidates with a combination of skills are sought, including disciplines such as biology, physiology, immunology, histopathology, pathogenesis, bioinformatics, and mathematical modeling. Applicants should possess strong scientific and/or computational skills, an affinity for hypothesis development and testing in a collaborative research environment, and a drive to learn new skills.  Excellent communication, presentation and reporting skills are essential, as well as the ability to work independently and as a team player. A PhD in biological sciences, computational biology, bioinformatics, or a related computer science discipline is required. MD or DVM candidates with such skills may also be considered, particularly in the areas of systems biology, physiology, immunology and histopathology.

The MaHPIC and HAMMER teams are highly collaborative, fast-paced, and deliverable-oriented, providing a learning environment with excellent working conditions, compensation, and career development opportunities for its team members.  The positions will be based at Emory University, at multiple campus locations, and candidates are expected to work closely with team members as required at Emory, The Georgia Institute of Technology (GA Tech) and the University of Georgia in Athens (UGA), as well as other national and international institutions.

Applicants should apply by sending a cover letter, CV, personal statement noting career goals, and the names and contacts of three references to Prof. Mary Galinski (mary.galinski@emory.edu) with "postdoctoral Fellowship Application' in the subject line of the message. The application should include information on the suitability of the applicant for the open positions and stress the specific talents they will bring to this program.

Multiple positions are available immediately.

Applications will be considered until the positions are filled.

Selected candidates will be interviewed by multiple faculty members comprising the consortia.

Emory University provides excellent benefits and a rewarding work environment, with the advantage of being located in the major, thriving city of Atlanta, GA, USA. People are drawn to work here to enrich, change and save lives. They are attracted by the opportunity to participate in the community life of a top-ranked university.  Emory ranks as the second-largest employer in the metro Atlanta area, with more than 29,300 people on the payroll as of Sept. 1, 2015.

Emory University is an equal opportunity/equal access/affirmative action employer fully committed to achieving a diverse workforce and complies with all Federal and Georgia State laws, regulations, and executive orders regarding non-discrimination and affirmative action.  Emory University does not discriminate on the basis of race, age, color, religion, national origin or ancestry, sex, gender, disability, veteran status, genetic information, sexual orientation, or gender identity or expression.

4. PhD Fellowship for molecular studies on Plasmodium vivax host parasite interactions mediated by exosomes: PVREX group, ISGlobal, Barcelona Institute for Global Health, Spain

The Plasmodium vivax and exosome research group (PVREX) (http://pvrex.com) is seeking for a self-motivated and enthusiastic student to pursue a 3-years PhD position on mechanistic insights of pathology mediated by exosomes in the human malaria caused by Plasmodium vivax. Exosomes are nanovesicles of endocytic origins initially identified in reticulocytes, the host cell for which Plasmodium vivax has a unique tropism, and presently known to act in inter-cellular communication and holding a promising potential as novel biomarkers of disease and vaccines.

The research is hypothesis driven and goals include unveiling in vivo distribution of exosomes in infections, identification of target human cells, OMICs analysis to unveil signaling pathways and development of functional assays and usage of rodent models to show their role in pathology. This project will be done in collaboration with Marcus VG Lacerda´s group at the Fundaçao de Medicina Tropical Dr Heitor Vieira Dourado, Manaus, Brazil. Thus, the position will require close collaboration with this Foundation and a willingness to spend time working there.

Candidates with a combination of skills are sought, including disciplines such as biology and computational biology. Applicants should possess strong scientific skills, an affinity for hypothesis development and testing in a collaborative research environment, and a drive to learn new skills.  Excellent written and oral English including presentation and reporting skills as well as the ability to work independently and as a team player, are essential. A master in biological sciences is required.

Applicants should apply by sending a cover letter, CV, personal statement noting career goals, and the names and contacts of three references to either Dr. Hernando Del Portillo (hernandoa.delportillo@isglobal.org) or Dr. Carmen Fernandez-Becerra (Carmen.fernandez@isglobal.org) with "PhD Fellowship Application' in the subject line of the message. The application should include information on the suitability of the applicant for the open position and stress the specific talents they will bring to this program.

Selected candidates will be interviewed personally or by skype. This position is available for 3 years. 

 

5. 

Postdoctoral Research Scientist in Malaria Vaccine Development
Centre for Cellular and Molecular Physiology, Jenner Institute, Henry Wellcome Building for Molecular Physiology, Roosevelt Drive, Headington, Oxford
Grade 7: Salary in the range £31,076 – £33,943 p.a.

Applications are invited for a Postdoctoral Research Scientist in Malaria Vaccine Development at the Jenner Institute located at the Centre for Cellular and Molecular Physiology, Wellcome Trust Centre for Human Genetics.

You will work on the development of a Plasmodium vivax malaria vaccine, including pre-clinical, pre-GMP and liaising with external contractors for the GMP development. You will have a PhD degree in a relevant biological sciences or related subject and demonstrable experience in VLP and protein production and purification, particularly using the HepB S Antigen as a platform. This project consists on production of a VLP in Pichia, purification using AKTA systems and production of additional proteins suitable for assessment of antibody responses in a future clinical trial. You will also support other projects that are reaching GMP production and clinical trial stages, as well as some at an earlier stage of pre-clinical development.

You will be required to support the Principal Investigator and other senior, junior researchers and students in the day-to-day work of this project. You will supply information to the team and project manager to support tracking progress against objectives and compiling project reports in a timely manner for efficient running of the projects.

You will work closely with Professor Arturo Reyes-Sandoval and his team and should be highly motivated, efficient, well-organised, pro-active, and able to take initiative and to work autonomously in a fast-paced, scientific environment, whilst reporting regularly to the Principal Investigator.

You will have a PhD in a relevant biological subject and significant proven experience in VLP production and GMP process development. You should have the ability to work independently and with own initiative whilst reporting regularly to Project Leader and project manager about work progress and assignment of priorities and resources with excellent interpersonal skills, including ability to form relationships with key stakeholders. You will have excellent verbal and written communication skills, including ability to communicate with people from multiple disciplines, particularly clinicians, scientists and bioinformaticians and excellent organisation skills, with the ability to prioritise tasks, adapt to changing demands and manage a complex workload of their own and that of other project members to work together to meet deadlines.

The post is fixed-term contract until 28 February 2018, with possibility of extension and funded by the Medical Research Council.

Please quote reference 126929 on all correspondence. You will be required to upload a CV and supporting statement as part of your online application.

Only applications received before 12.00 midday on Monday 13 February 2017 will be considered.

Contact Person : Joanne White Vacancy ID : 126929
Contact Phone : 01865 287507 Closing Date : 13-Feb-2017
Contact Email : personnel@well.ox.ac.uk